https://www.ceesdekker.net Secrets
https://www.ceesdekker.net Secrets
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2009, discovery of a fresh phenotype for bacteria in slender nanofluidic slits; and initially detection of area protein structures along DNA working with good-state nanopores
1996, very first mesoscopic demand density waves devices; and 1st electrical measurements on only one metallic nanocluster between nanoelectrodes
Multicolor imaging in the bacterial nucleoid and mobile division proteins with blue, orange, and in the vicinity of-infrared fluorescent proteins
Because 2000, Dekker has shifted the main concentration of his function to biophysics the place he scientific studies the properties of solitary biomolecules and cells utilizing the resources of nanotechnology. This change of area was driven by his fascination for your extraordinary performing of biological molecular constructions, in addition to because of the long-time period viewpoint that many appealing discoveries may be predicted During this field.[5] Existing traces of exploration in his biophysics team are during the parts of:[six]
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Example (three) of bending configurations in 3D simulations of DNA rods on nanopores. A part of the membrane is revealed in grey, the rim with the pore is highlighted in crimson, along with a 3D rendering from the movement in the DNA rod is displayed.
Because 2000 he moved to single-molecule biophysics and nanobiology, with exploration from DNA supercoiling scientific tests of nucleosomes and ceesdekker.net DNA fix proteins to DNA translocation via nanopores. Recently his investigate has centered on studying mobile division with microorganisms on chip, whilst his ultimate fascination is during the course of recognizing artificial cells.
Atomic power microscopy demonstrates that vaccinia topoisomerase IB generates filaments on DNA in a cooperative style
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‘The fantastically delicate way where aspects in character perform never ceases to amaze me. If we address the puzzle of how lifetime came into getting, I anticipate that my amazement at the complexity of generation could have improved and with it my awe for your greatness from the Creator.’
Considering that 2000 he moved to single-molecule biophysics and nanobiology, with exploration from scientific studies of DNA loop extrusion and supercoiling to DNA translocation by way of nanopores. Much more a short while ago his analysis has centered on learning chromatin composition and cell division with micro organism on chip, whilst he is usually trying to finally Construct artificial cells from the bottom up.
Cees Dekker is Distinguished College Professor at TU Delft. Properly trained to be a physicist, he pioneered nanotechnology with many discoveries on carbon nanotubes in the 1990s. Since 2000, he moved to one-molecule biophysics and nanobiology. His present-day investigate concentrates on (i) nanopores for protein sequencing; (ii) chromosome framework, particularly SMC motor protein; and (iii) creating a living synthetic mobile from lifeless molecules. Dekker is an elected member of your KNAW and fellow to your APS plus the IOP.
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Supercoiling-dependent DNA binding: quantitative modeling and purposes to bulk and solitary-molecule experiments